Activation and intrinsic γ-secretase activity of presenilin 1
نویسندگان
چکیده
Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065; Department of Pharmacology, Department of Physiology, Biophysics and Systems Biology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021; Center for Molecular Neurobiology, University of Chicago, Chicago, IL 60637; and Department of Chemical Engineering and Department of Biomedical Engineering, City College of the City University of New York, New York, NY 10031
منابع مشابه
Overexpression of N141I PS2 increases γ-secretase activity through up-regulation of Presenilin and Pen-2 in brain mitochondria of NSE/hPS2m transgenic mice
Alzheimer's disease (AD) is known to induce alterations of mitochondrial function such as elevation of oxidative stress and activation of apopotosis. The aim of this study was to investigate the effects of human Presenilin 2 mutant (hPS2m) overexpression on the γ-secretase complex in the mitochondrial fraction. To achieve this, alterations of γ-secretase complex expression and activity were det...
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